The USS Caperton has had several Commanders during its various commissions. Below is a list which to the best of my knowledge is accurate (if incomplete). Please don't hesitate to reach out to me with corrections!
| Commanders WWII | |
| 30 July 1943 | Commissioned, Boston Navy Yard, Unit of Destroyer Division 100, Destroyer Squadron 50. |
| 30 July 1943 - 27 August 1944 | Commanding Officer, Commander Wallace J. Miller, United States Navy |
| 27 August 1943 - 12 July 1945 | Commanding Officer, Commander George K. Carmichael, United States Navy. |
| 12 July 1945 | Commanding Officer, Lieutenant Commander Will P. Starnes, United States Navy. |
| USS Caperton Decommissioned from 12 July 1945 to 4 June 1951 | |
| Commanders Korea | |
| 4 June 1951 - 1952 | Commanding Officer, Commander George M. Hawes, United States Navy |
| 1952-1954 | Commanding Officer, Commander Edward A. Sandor, United States Navy |
| 1954-1956 | Commanding Officer, Commander Arthur Parris, United States Navy |
| 1956-1958 | Commanding Officer, Commander James B. McCormick, United States Navy |
| Commanding Officer, Lieutenant Commander Charles R. Hickman, United States Navy | |